Sponsored by The Cavalier
King Charles Spaniel Club and the Kennel Club Charitable Trust.
Brendan Corcoran has presented an initial report on the results of their three-year
project. This report follows.
Dr Corcoran said that their research has clarified a whole range of changes
that occur in diseased valves and they now know a lot more about what is going
on in the mitral valve than previously. But they still do not know why the disease
He and his colleagues will spend the next few months analysing the data collected
and then decide the best way forward. He considers that the major conundrum
that still exists is why the CKCS is more prone to the disease at an earlier
stage in life than other breeds. He mentions that nearly all the geriatric dogs
from which the valve samples were collected, showed evidence of the disease.
They had only limited success in obtaining heart valves from Cavaliers. The
majority supplied came from cross breeds and some pedigree dogs including Beagles
which are also prone to MVD.
When the data has been thoroughly considered, Dr Corcoran has promised to provide
a more detailed overview of the research in a form that has less specific scientific
CKCS Club Chairman
Canine Mitral Disease Project Report
This study is financed by the Cavalier King Charles Spaniel Club and the Kennel
Club Charitable Trust. The main use of funds is in the support of a PhD student
Richard Han. Mr Han is due to finish his course of study end of January 2007,
and expects to submit his thesis in Autumn 2007.
The study's broad aims are to better understand the pathological changes that
occur in the mitral valves of dogs with myxomatous degeneration (endocadiosis).
The project has utilised a variety of techniques to try and elucidate the changes
that occur in diseased valves, and some of the results to date have been presented
at scientific meetings. Additionally, complimentary studies have been organised
involving other students and staff at the R(D)SVS and utilising the resources
that have become available from the main study.
The work to date can be divided into the following categories. For some of these
studies we have recruited other students and staff members as the project has
evolved, and Richard Hans role has been to coordinate tissue sourcing and provide
technical support and guidance.