Sustainable Breeding of Pedigree Dogs
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  Lets have a look at some figures.

When the diversity is above 100, than in principle we can select on individual animals, although we know that this can very quickly bring the diversity below 100!
With a diversity between 50 and 100, strict selection can very quickly reduce the diversity to a dangerous level.
With a diversity below 50, any form of human selection is not advisable and dangerous for the future of the population.